Correlación del índice de masa corporal (IMC) con la expresión del ARNm de receptores nucleares en tejido adiposo de mujeres con IMC de entre 18.5 en adelante

Abstract

Obesity is a chronic, complex and multifactorial induced genetic and environmental components, an obese person is at risk for many diseases and health problems. Today, Mexico ranks first inchildhood obesity and adult obesity in second in the world, theNational Survey of Health and Nutrition (ENSANUT) 2005showed that the number of obese people in Mexico has accelerated much faster than that estimated, due to the obesity problem that triggers the development to be evaluated in detail. The body mass index or BMI is the index most commonly used toestimate the percentage of body fat in obese people, many articles point out as the most versatile for the simplicity of its calculation, one of the strengths of estimating weight by BMI is80% correlated with the amount of adipose tissue which correlates well in direct proportion to the risk of disease. Gene expression is regulated by interaction with the environment, there are several nuclear receptors that function as transcription factors that regulate energy homeostasis and are key genes inlipid metabolism and beta oxidation between these genes is thefamily PPARs, which consists of three members, PPAR , PPAR     PPAR     PPARs to exert their function usually form homodimers or heterodimers among themselves or with other nuclear receptors. Other genes important in adipogenesisin lipid metabolism, inflammation and apoptosis are also genes belonging to the family of orphanreceptors specifically including the NR4As Nor1 and Nurr1 and Nurr 77. In addition to these genes are important cofactors involved inlipid metabolism that are essential to the functioning of genes, in the case of PPAR  and  are their cofactors PGC1 PGC1 and in the case of NR4A family members is RIP140. The number of biopsies used (n = 54) divided into three groups of 18 samples each (thin, moderately obese and morbidly obese) should be increased and better established in relation to a stratification of visceral adipose tissue biopsies and subcutaneous adipose tissue, which may represent betterstatistical significance. It seems that members of the superfamily of nuclear receptors correlate gene expression level with differentbody mass indexes, which has never been described and if confirmed would represent a significant contribution to theunderstanding of adipose tissue metabolism possibly to thepathogenesis of a complex disease such as obesity.