EFECTO DE TIBOLONA SOBRE BIOMARCADORES ASOCIADOS A DETERIORO COGNITIVO LEVE EN PACIENTES MENOPAUSICAS

Abstract

Menopause is the permanent cessation of menstruation and occurs from the 40 years of age due to ovarian dysfunction, which in turn, increase of cardiovascular risk, insulin resistance, depression, mild cognitive impairment and osteoporosis. This was the basis for replacement therapy with estrogen and progesterone, however, it was reported to induce effects, which led to the development of synthetic drugs such as tibolone, of which improves improves climacteric symptoms, bone mineralization, but its effect on cognitive ability has not been defined and further mechanisms that might modulate these effects. In the present study, were involved 20 postmenopausal patients who received tibolone (as HRT), which were evaluated anthropometric measures, cognitive function (neuropsychological tests) and damage to lipids (MDA/4-HNE). Treatment with tibolone for 3 months did not modify body mass index, fat percentage and waist-hip ratio, but decreased damage to lipids (MDA/4HNE) and increased the score in the areas of memory in the Neuropsi test (decrease mild cognitive impairment), we found an inverse correlation between both parameters, in example, when damage to lipids is higher, the Neuropsi test scores is lower.