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http://repositoriodigital.ipn.mx/handle/123456789/8535
Título : | Hypolipidemic Activity of New Phenoxyacetic Derivatives Related to X-Asarone with Minimal Pharmacophore Features |
Autor : | Cruz lopez, María del Carmen |
Palabras clave : | hypocholesterolemia pharmacophores |
Fecha de publicación : | 25-nov-2012 |
Resumen : | Five new series of potential hypolipidemic agents 3-7 were synthesized, in order to establish the minimal pharmacophore features assoc iated to the potent h ypocholesterolemic acti vity of natural :x-asarone (1) and synthetic clofibrate mimetic derivatives 2. The compounds were exam ined in hyperlipidemic male mice after oral administration of 25, 50, and 1 00 mg/Kg for 6 days. The isomeric series of acids and esters 3a-3c and 4a-4c were unexpectedly less active than the most simpl e structural isomeric compounds S-7. This reveals that the phenoxyacetic acid scaffold car rying a h ydrocarbon side chain, also found in deri vatives 2, seems to be the most favorable lea d for further development of potent hypolipidemic drugs. |
Descripción : | Artículo |
URI : | http://www.repositoriodigital.ipn.mx/handle/123456789/8535 |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Articulos ISI CarmenCruz-7.pdf | 1.21 MB | Adobe PDF | Visualizar/Abrir |
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