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Título : | Regioselective and Versatile Synthesis of Indoles via Intramolecular Friedel–Crafts Heteroannulation of Enaminones |
Autor : | Cruz lopez, María del Carmen |
Palabras clave : | indoles, enaminones |
Fecha de publicación : | 25-nov-2012 |
Resumen : | A new approach is described for the synthesis of substituted indoles 5, through an intramolecular and regioselective Friedel–Crafts cyclization of enaminones 6a–h catalyzed by Lewis acids. Compounds 6 were prepared from the 2-anilinocarbonyl compounds 7, by treatment with DMFDMA under thermal or microwave (MW) irradiation conditions. An alternative and shorter one-pot two-step synthesis of indoles 5 was achieved starting from compounds 7 and promoted by MW radiation, including the elusive 2-acetylindoles 5i–m. |
Descripción : | Artículo |
URI : | http://www.repositoriodigital.ipn.mx/handle/123456789/8532 |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Articulos ISI CarmenCruz-4.pdf | 112.89 kB | Adobe PDF | Visualizar/Abrir |
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