EFECTO DE LA METFORMINA EN LA FUNCIÓN SISTOLICA Y DIASTOLICA DEL VENTRÍCULO IZQUIERDO VALORADO POR ECOCARDIOGRAMA EN PACIENTES CON SÍNDROME METABÓLICO

Abstract

Introduction: Metabolic syndrome (MS) is a public health problem in Mexico for its high incidence and pathogenicity. According to the criteria of the International Diabetes Federation (IDF) 2005 diagnostic criteria of SM include abdominal obesity and alterations blood glucose, cholesterol high density lipoprotein (HDL-C), triglycerides (TG) and blood pressure. One of the common complications of MS left ventricular dysfunction (VI), altering both systolic and diastolic function, that often comes to developing heart failure clinic. The antidiabetic drug metformin (MT) exerts beneficial effects not only on glycemic control but also improves inflammation and endothelial dysfunction. Material and methods Results: At baseline echocardiography, according to the E / A transmitral flow was impaired LV relaxation in all patients, systolic function was preserved in all detected cases according to the normal rates. In the control group was observed at the end of the study a slight increase in LV end-diastolic diameter, although within normal LVEF and DTI S wave reduction were observed at study but within the acceptable values with respect diastolic function to a significant decrease of SR where already was altered. In the experimental group LVEF, DTI S wave and peak : We included 50 patients of both sexes with at least 3 criteria for MS by the 2005 version of the FID, which were randomly divided into 2 groups and received the same dietary advice; the control group (C) was treated in this way, the experimental group also received metformin (MT), a single dose of 850 mg/day. Were performed in both groups at baseline and two echocardiograms a further 6 months later. The variables studied were: ventricular ejection fraction (LVEF), indexed LV mass, wall thickness ratio of the radius (h / r), the system was analyzed by Doppler transmitral flow velocity, the annular tissue velocity mitral and by tracking technique is evaluated speckel wall deformation (strain S) and rate of deformation (strain rate SR). 7 systolic Strain (SSP) significantly increased the mass and the ratio h / r decreased, finally in this group of DTI E wave and E / A ratio increased significantly at the end of the study. Finally, when comparing the control group with experimental group shows a significant improvement in systolic function observed in the LVEF, the DTI S wave and the SSP, has also diastolic function improvement observed in DTI E-wave and there is a tendency to diastolic SR improved. Conclusion: Patients treated with metformin 850 mg daily had an improvement in systolic and diastolic after 6 months of treatment.