Asociación del Polimorfismo G894T en el gene de la Enzima Sintasa del Oxido Nítrico Endotelial (eNos) con el Infarto Agudo del Miocardio.

Abstract

Background. The polymorphism G894T of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial. The aim of this study was examined the possible association of the G894T with premature ST elevation myocardial infarction (STEAMI) in young Mexican population. Methods. In a case-control study 180 unrelated patients with STEMI ≤45 years of age, who were admitted to a cardiovascular intense care unit and 180 apparently healthy controls matched by age were recruited from January 2008 and March 2009. The polymorphism G894T was determined in all participants by a polymerase chainreaction- restriction fragment length polymorphism assay (PCR-RFLP). Results. There was a significant difference in the genotype distribution between two groups (P=0.001). The allele Asp occurred more frequently in the patients group (P=0.001). There were independent factors for STEMI: the Asp allele (OR 2.2, 95%CI 1.1- 3.5, P=0.03), smoking (OR 5.0, 95% CI 3.1-8.2, P<0.001), hypertension (OR 2.0, 95%CI 1.0-3.5, P=0.03), family history of cardiovascular disease, (OR 3.7, 95% CI 2.0-4.6, P=0.02), and dyslipidemia (OR 3.4, 95%CI 2.0-6.3, P=0.02). Conclusions. The Asp allele from the Gu298Asp polymorphism represents an independent risk factor for premature STEAMI in Mexican population.