RAPIDEZ DE INICIO DEL SURFACTANTE PROFILÁCTICO Y DEPENDENCIA DE OXÍGENO EN RECIÉN NACIDOS DE ALTO RIESGO

Abstract

Background. The most prevalent respiratory disease in preterm infants less than 32 WGA is respiratory distress syndrome, being bronchopulmonary dysplasia a frequent complication. Current recommendations are to administer prophylactic surfactant before postnatal minute 30 and ideally before minute 15. It is not clear whether this really modifies the occurrence of respiratory distress syndrome or bronchopulmonary dysplasia. Objective. To establish whether there is a correlation between prophylactic surfactant timing and oxygen dependence in preterm infants in whom it has been administered. Methods. A retrospective correlation and regression analysis of prophylactic surfactant timing and oxygen dependence time in days was done. We randomly selected preterm infants who had prophylactic surfactant administration. Results. We analyzed 46 preterm infant´s data. The median GA was 29.5 weeks (range 25.2-33.0 WGA) and median weight was 1055g (range 640-1250g). Median postnatal age at surfactant administration was 24 minutes (range 8-34 minutes). Median oxygen time dependence was 51 days (range 1-118 days). There was no correlation in univariate analysis between postnatal age at surfactant administration and oxygen time dependence. This result was maintained after multiple variable transformations. It was also true after analysis of oxygen inspired fraction at 36 weeks post conceptional age or at discharge. There was no correlation with other morbidity variables at short or long term. Conclusions. There is no correlation between the postnatal time of prophylactic surfactant administration and oxygen dependence time, bronchopulmonary dysplasia frequency or short and long term morbidity in preterm infants who underwent prophylactic surfactant administration.