EXPRESION DEL GEN ABCB1 Y DE CITOCINAS PROINFLAMATORIAS EN TEJIDO MUSCULAR Y ADIPOSO DE RATAS SPRAGUE DAWLEY BAJO UN ESTIMULO DE EJERCICIO Y/O DIETA

Abstract

Introduction: physical exercise reduces the risk of cardiovascular disease, providing great benefits to our health. Diet plays a vital role in our health and the excess of some food favors the increase of adipose tissue as a result we can present with obesity, adipose tissue undergoes a chronic inflammatory process and this favors the growth of some interleukins. The aim of this study was to analyze the gene expression of ABCB1 and pro-inflammatory cytokines IL-1B induced by exercise and / or high fat diet in Sprague Dawley rats. Material and methods: We performed a longitudinal, prospective and analytical intervention. In thirty-five Sprague Dawley rats were divided into four groups. A group or a control group with normal diet, the fat diet group two, group three with mild fatty diet plus exercise group and four more intense exercise. Results: We analyzed the expression of ABCB1 genes and IL-1B in adipose tissue and muscle tissue where it was found that ABCB 1 in adipose tissue in the fat diet group had more intense exercise greater expression with respect to the other groups but without achieving statistical significance and muscle fat diet group exercise more mild expression of ABCB 1 had lower expression compared to other groups. Conclusions: Although the study met the overall objective results were not statistically significant, it gives us the pattern to open new research to determine how their values interleukins increase during exercise.