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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | CRUZ LÓPEZ, MARÍA DEL CARMEN | - |
dc.date.accessioned | 2012-11-28T22:53:19Z | - |
dc.date.available | 2012-11-28T22:53:19Z | - |
dc.date.issued | 2012-11-28 | - |
dc.identifier.uri | http://www.repositoriodigital.ipn.mx/handle/123456789/8638 | - |
dc.description | Article | es |
dc.description.abstract | A series of a-asarone-based analogues was designed by conducting docking experiments with published crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a highly hypocholesterolemic in vivo activity in a murine model, as predicted by previous docking studies. In agreement with this model, the polar groups attached to the benzene ring could play a key role in the enzyme binding and probably also in its biological activity, mimicking the HMG-moiety of the natural substrate. The hypolipidemic action mechanism of these compounds was investigated by developing a simple, efficient, and novel model for determining HMG-CoA reductase inhibition. The partial purification of the enzyme from Schizosaccharomyces pombe allowed for testing of a-asarone- and fibrate-based analogues, resulting in positive and significant inhibitory activity. | es |
dc.description.sponsorship | Instituto Politécnico Nacional CIBA-Tlaxcala | es |
dc.language.iso | en | es |
dc.subject | Alpha-asarone | es |
dc.subject | Docking | es |
dc.title | Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors | es |
dc.type | Article | es |
dc.description.especialidad | Medico-Biológicas | es |
dc.description.tipo | es | |
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