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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.advisor | Salas-Benito, Juan Santiago | - |
dc.contributor.author | Salas-Benito, Juan Santiago | - |
dc.contributor.author | Reyes-Del Valle, Jorge | - |
dc.contributor.author | Salas-Benito, Mariana | - |
dc.contributor.author | Ceballos-Olvera, Ivonne | - |
dc.contributor.author | Mosso, Clemente | - |
dc.contributor.author | del Angel, Rosa María | - |
dc.date.accessioned | 2012-10-11T20:31:08Z | - |
dc.date.available | 2012-10-11T20:31:08Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Salas-Benito J, Reyes-del Valle J, Salas-Benito M, Ceballos-Olvera I, Mosso C, del Angel RM. Evidence that the 45 kDa glycoprotein, part of a putative dengue virus receptor complex in the mosquito cell line C6/36, is a heat shock-related protein. Am J Trop Med Hyg. 2007. 77(22): 283-290 | es |
dc.identifier.issn | 0002-9637 | - |
dc.identifier.uri | http://www.repositoriodigital.ipn.mx/handle/123456789/7258 | - |
dc.description | Artículo científico | es |
dc.description.abstract | Dengue virus (DENV) is transmitted to humans by mosquitoes of the genus Aedes. Although several molecules have been described as part of DENV receptor complex in mosquito cells, none of them have been identified. Our group characterized two glycoproteins (40 and 45 kD) as part of the DENV receptor complex in C6/36 cells. Because identification of the mosquito cell receptor has been unsuccessful and some cell receptors described for DENV in mammalian cells are heat-shock proteins (HSPs), the role of HSPs in DENV binding and infection in C6/36 cells was evaluated. Our results indicate that gp45 and a 74-kD molecule (p74), which interact with DENV envelope protein, are immunologically related to HSP90. Although p74 is induced by heat shock, gp45 apparently is not. However, these proteins are relocated to the cell surface after heat-shock treatment, causing an increase in virus binding without any effect on virus yield. | es |
dc.description.sponsorship | Secretaría de Investigación y Posgrado of IPN (SIP 20050605) Nacional Researcher System Comisión de Operación y Fomento a las Actividades Académicas-IPN Consejo Nacional de Ciencia y Tecnología (39946-Q) | es |
dc.language.iso | en | es |
dc.publisher | American Journal of Tropican Medicine and Hygiene | es |
dc.subject | Dengue | es |
dc.subject | Aedes albopictus | es |
dc.subject | Células C6/36 | es |
dc.subject | Receptores | es |
dc.subject | Proteínas de choque térmico | es |
dc.title | Evidence that the 45 kDa glycoprotein, part of a putative dengue virus receptor complex in the mosquito cell line C6/36, is a heat shock-related protein | es |
dc.type | Article | es |
dc.description.especialidad | Medicina | es |
dc.description.tipo | 8 | es |
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Evidence that the 45-kD glycoprotein, part of a putative dengue virus receptor complex in the mosquito cell line C6-36, is a heat-shock related protein.pdf | Artículo completo | 336.53 kB | Adobe PDF | Visualizar/Abrir |
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