Aryloxyacetic esters structurally related to a-Asarone as potential antifungal agents

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Jiménez Montejo, Fabiola Eloísa	-
dc.date.accessioned	2013-02-26T18:28:36Z	-
dc.date.available	2013-02-26T18:28:36Z	-
dc.date.issued	2013-02-26	-
dc.identifier.uri	http://www.repositoriodigital.ipn.mx/handle/123456789/13814	-
dc.description	Article	es
dc.description.abstract	A series of aryloxyacetic ester analogues 8–13 was synthesized based on the potential pharmacophores of the antifungal agents a-Asarone (1) and 2–5. Their antifungal activity was tested in vitro for their growth inhibitory activities against pathogenic fungi. The in vitro antifungal evaluation of these alkyl and aryl esters shows that derivatives 10 displayed the highest antifungal and fungicidal activities against Cryptococcus neoformans and C. gattii. These results support the idea that the phenoxyacetic frame is a potent pharmacophore for the design of potential antifungal drugs.	es
dc.description.sponsorship	Instituto Politécnico Nacional CIBA-Tlaxcala	es
dc.subject	Antifungal activity	es
dc.title	Aryloxyacetic esters structurally related to a-Asarone as potential antifungal agents	es
dc.type	Article	es
dc.description.especialidad	Medico-Biológicas	es
dc.description.tipo	PDF	es
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