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Título : | ENZYMATIC REDUCTION OF 9-METHOXYTARIACURIPYRONE BY SACCHAROMYCES CEREVISIAE AND ITS ANTIMYCOBACTERIAL ACTIVITY. |
Autor : | Alvarez Fitz, Patricia |
Fecha de publicación : | 19-feb-2013 |
Resumen : | Biotransformation processes have been successfully utilized to obtain products of pharmaceutical, chemical, food, and agricultural interest, which are difficult to obtain by classic chemical methods. The compound with antituberculous activity, 9-methoxy-tariacuripyrone (1), isolated from Aristolochia brevipes, was submitted to biotransformation with the yeast Saccharomyces cerevisiae under culture, yielding 5-amino-9-methoxy-3,4-dihydro-2H-benzo[h]chromen-2-one (2). The structure of 2 was elucidated on the basis of spectroscopic analyses. The results mainly show the reduction of the double bond and the nitro group of compound 1. Metabolite 2 demonstrated an increase in anti-tuberculous activity (MIC = 3.12 μg/mL) against the drug-sensitive Mycobacteriumtuberculosis (H37Rv) strain, with respect to that shown by 1. |
Descripción : | http://www.mdpi.com/1420-3049/17/7/8464 |
URI : | http://www.repositoriodigital.ipn.mx/handle/123456789/13206 |
Aparece en las colecciones: | Publicaciones |
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Fichero | Descripción | Tamaño | Formato | |
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Articulo 15-2012.pdf | 178.79 kB | Adobe PDF | Visualizar/Abrir |
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