EFECTO DEL ESTRÉS AGUDO INDUCIDO POR INMOVILIZACIÓN EN LA SECRECIÓN Y TRANSPORTE DE IgA EN DUODENO E ILEON DE RATONES BALB/c

Abstract

Different studies have shown the effect of stress on the immune system. Within these effects has been found an increase in the levels of IgA intraluminal of the small intestine. However it is not known whether this effect is caused by an increase in intestinal permeability induced by the release of catecolaminas released during stress, or by an increase in the secretion and transport of IgA in 15 the intestinal mucosa. The general objective of this study was to determine if the acute stress modifies the secretion and transport of IgA in the proximal and distal segment of small intestine Balb/C. In this study was considered 2 study groups: 1) control group and 2) group of stress. The control group was under stress-free. In the problem group, acute stress was induced by immobilization of the 4 tips and the tail of mice for 4 hours. Serum samples were obtained for the determination corticosterona and dissected the duodenum and the ileum of which were obtained intestinal fluid, Peyer's patches and epithelial cells for the quantification of IgA, determination of the percentage of plasma cells producing IgA and expression of pIgR and IgA, respectively.