http://repositoriodigital.ipn.mx/handle/123456789/2844 2026-04-18T00:22:17Z http://repositoriodigital.ipn.mx/handle/123456789/13815 Title: ANewSynthetic Route of 2-Aroyl- and 2-Benzyl-Benzofurans and their Application in the Total Synthesis of a Metabolite Isolated from Dorstenia gigas Authors: Jiménez Montejo, Fabiola Eloísa Abstract: The Lewis acid-catalyzed cyclization of the (Z)-3-(dimethylamino)-2-aryloxy-1-arylprop-2-en-1-ones 4a–h leads to a regioselective and short synthesis of 2-aroylbenzofurans 2a–h. TheWolff–Kishner reduction of the latter yielded a series of substituted 2-benzylbenzofurans 3a–h. This methodology was applied in the first total synthesis of the metabolite 2-(4-hydroxybenzyl)-6-methoxybenzofuran 1, which was isolated from the tropical plant Dorstenia gigas, and obtained through a six-step route and in a 24% overall yield. Description: Article 2013-02-26T00:00:00Z http://repositoriodigital.ipn.mx/handle/123456789/13814 Title: Aryloxyacetic esters structurally related to a-Asarone as potential antifungal agents Authors: Jiménez Montejo, Fabiola Eloísa Abstract: A series of aryloxyacetic ester analogues 8–13 was synthesized based on the potential pharmacophores of the antifungal agents a-Asarone (1) and 2–5. Their antifungal activity was tested in vitro for their growth inhibitory activities against pathogenic fungi. The in vitro antifungal evaluation of these alkyl and aryl esters shows that derivatives 10 displayed the highest antifungal and fungicidal activities against Cryptococcus neoformans and C. gattii. These results support the idea that the phenoxyacetic frame is a potent pharmacophore for the design of potential antifungal drugs. Description: Article 2013-02-26T00:00:00Z http://repositoriodigital.ipn.mx/handle/123456789/13813 Title: Design, synthesis, and docking of highly hypolipidemic agents:Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors Authors: Jiménez Montejo, Fabiola Eloísa Abstract: A series of a-asarone-based analogues was designed by conducting docking experiments with published crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a highly hypocholesterolemic in vivo activity in a murine model, as predicted by previous docking studies. In agreement with this model, the polar groups attached to the benzene ring could play a key role in the enzyme binding and probably also in its biological activity, mimicking the HMG-moiety of the natural substrate. The hypolipidemic action mechanism of these compounds was investigated by developing a simple, efficient, and novel model for determining HMG-CoA reductase inhibition. The partial purification of the enzyme from Schizosaccharomyces pombe allowed for testing of a-asarone- and fibrate-based analogues, resulting in positive and significant inhibitory activity. 2010 Elsevier Ltd. All rights reserved. Description: Article 2013-02-26T00:00:00Z http://repositoriodigital.ipn.mx/handle/123456789/13812 Title: New Approach for the Construction of the Coumarin Frame and Application in the Total Synthesis of Natural Products Authors: Jiménez Montejo, Fabiola Eloísa Abstract: New Approach for the Construction of the Coumarin Frame and Application in the Total Synthesis of Natural Products Description: Article 2013-02-26T00:00:00Z