http://repositoriodigital.ipn.mx/handle/123456789/2838 2026-04-22T19:00:01Z http://repositoriodigital.ipn.mx/handle/123456789/12374 Title: Hypolipidemic Effect of Seed Oil of Noni (Morinda citrifolia) Authors: Cruz López, María del Carmen Abstract: Morinda citrifolia, has been reported to posses different biological activities and almost all parts of this have been studied phytochemically. However there are few studies on the seeds of fruit. The objective of present study was investigated the effect to Noni Seed Oil (NSO) on serum lipid levels in normolipidemic and hyperlipidemic induced mice. We find that administration of noni oil causes a reduction in total cholesterol and triglycerides levels in both models. However hypolipidemic effect is higher when hyperlipidemia is presented. Description: Hypolipidemic Effect of Seed Oil of Noni (Morinda citrifolia) 2013-01-30T00:00:00Z http://repositoriodigital.ipn.mx/handle/123456789/12373 Title: Aryloxyacetic esters structurally related to a-Asarone as potential antifungal agents Authors: Cruz López, María del Carmen Abstract: A series of aryloxyacetic ester analogues 8–13 was synthesized based on the potential pharmacophores of the antifungal agents a-Asarone (1) and 2–5. Their antifungal activity was tested in vitro for their growth inhibitory activities against pathogenic fungi. The in vitro antifungal evaluation of these alkyl and aryl esters shows that derivatives 10 displayed the highest antifungal and fungicidal activities against Cryptococcus neoformans and C. gattii. These results support the idea that the phenoxyacetic frame is a potent pharmacophore for the design of potential antifungal drugs. Description: Aryloxyacetic esters structurally related to a-Asarone as potential antifungal agents 2013-01-30T00:00:00Z http://repositoriodigital.ipn.mx/handle/123456789/12372 Title: Efficient Synthetic Approach to Substituted Benzo[b]furans and Benzo[b] thiophenes by Iodine-Promoted Cyclization of Enaminones Authors: Cruz López, María del Carmen Abstract: An efficient synthetic approach to the substituted benzo[b]furan and benzo[b]thiophene scaffolds by iodine-mediated cyclization of the corresponding enaminones is described. This protocol was applied to a large series of these latter precursors to afford the respective benzoheterocycles substituted at the C-2 position by a carbonyl group functionality. A study of the factors that control this process reveals that the reactivity depends on the presence of electron-donor groups in the aryl ring of the aryloxycarbonylic and arylthiocarbonylic moieties. Description: Efficient Synthetic Approach to Substituted Benzo[b]furans and Benzo[b] thiophenes by Iodine-Promoted Cyclization of Enaminones 2013-01-30T00:00:00Z http://repositoriodigital.ipn.mx/handle/123456789/12371 Title: New Approach for the Construction of the Coumarin Frame and Application in the Total Synthesis of Natural Products Authors: Cruz López, María del Carmen Abstract: A new synthetic approach is described for building the coumarin scaffold through the Lewis acidpromoted cyclization of novel aryl 3-(dimethylamino)prop-2-enoates 2a – 2f. The latter precursors were prepared via aminomethylenation of the corresponding aryl acetates 4a – 4f with the Bredereck reagent. This approach was used for the synthesis of biologically active natural compounds 1a – 1f, through a three-step procedure starting from the corresponding phenols. Description: New Approach for the Construction of the Coumarin Frame and Application in the Total Synthesis of Natural Products 2013-01-30T00:00:00Z